βCaMKII overexpression in the dentate gyrus does not result in depression- and anxiety-like behaviors in mice

Beta-Ca2+/calmodulin-dependent protein kinase II (βCaMKII) is known as a powerful regulator of lateral habenula neuron function and key molecular determinant depression. βCaMKII also abundant in the hippocampus, especially dentate gyrus (DG). However, whether DG involved emotional behaviors remains unknown. In this study, using βCaMKII-F90G transgenic mice, which overexpression restricted to DG, we demonstrated that has no effect on level anxiety mice open field test or light–dark box test. Moreover, tail suspension forced swim showed depression their littermates was comparable. Taken together, our findings indicate does not result depression- anxiety-like provide evidence brain region specific.